My Friend's Little Sister Has It In for Me! is a tV series anime that premiered in fall 2025, produced by BLADE.

About the production: the story comes from a light novel, there are 12 episodes of about 23 minutes and its current status is "finished".

Its main genres are comedy, romance and slice of life, with themes such as Heterosexual, Love Triangle, Fake Relationship and Tsundere.

On AniList, My Friend's Little Sister Has It In for Me! has an average score of 65%, a good score, and appears on 52,221 users' lists.

For high schooler Akiteru Ooboshi, the whole youthful experience thing—like fun, friendships, and even having a girlfriend—is a complete waste of time. So when his best friend’s sister, Iroha Kohinata, keeps teasing him, Akiteru naturally finds it annoying. She practically lives in his room, she’s always on his bed, she’s just a raging storm of clinginess! Why is she only annoying around him?! (Source: Crunchyroll)

Official synopsis from AniList.